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Title
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The molecular machinery of regulated cell death
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Author
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Abstract
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| Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the current state of the art regarding non-apoptotic types of RCD, including necroptosis, pyroptosis, ferroptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis and oxeiptosis. The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss. |
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Language
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English
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Source (journal)
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Cell research / Academia Sinica. Shanghai Institute of Cell Biology. - Shanghai
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Publication
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London
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Nature publishing group
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2019
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ISSN
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1001-0602
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DOI
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10.1038/S41422-019-0164-5
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Volume/pages
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29
:5
(2019)
, p. 347-364
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ISI
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000466153400005
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Pubmed ID
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30948788
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Full text (Publisher's DOI)
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Full text (open access)
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