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Title
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Caucasian ethnicity, but not treatment cessation is associated with HBsAg loss following nucleos(t)ide analogue-induced HBeAg seroconversion
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Author
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Abstract
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| It is well appreciated that ethnicity influences the natural history and immune responses during a chronic hepatitis B infection. In this study, we explore the effect of ethnicity and treatment cessation on Hepatitis B surface Antigen (HBsAg) seroclearance in patients with Nucleos(t)ide Analogue (NA)-induced Hepatitis B e Antigen (HBeAg) seroconversion. We performed a multi-ethnic, multicentric observational cohort study. The analyzed cohort consisted of 178 mono-infected, predominantly male (75.3%) chronic hepatitis B patients of mixed ethnicity (44.4% Asians, 48.9% Caucasians) with nucleos(t)ide analogue-induced HBeAg seroconversion. Treatment was withdrawn in 105 patients and continued in 73, leading to HBsAg loss in 14 patients off- and 16 patients on-treatment, respectively. Overall, HBsAg loss rates were not affected by treatment cessation (hazard ratio 1.45, p = 0.372), regardless of consolidation treatment duration. Caucasian ethnicity was associated with an increased chance of HBsAg loss (hazard ratio 6.70, p = 0.001), but hepatitis B virus genotype was not (p = 0.812). In conclusion, ethnicity is the most important determinant for HBsAg loss after NA-induced HBeAg seroconversion, with up to six-fold higher HBsAg loss rates in Caucasians compared to Asians, irrespective of treatment cessation and consolidation treatment duration. |
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Language
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Dutch, English
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Source (journal)
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Viruses
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Publication
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2019
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ISSN
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1999-4915
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DOI
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10.3390/V11080687
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Volume/pages
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11
:8
(2019)
, 10 p.
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Article Reference
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687
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ISI
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000482993900055
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Pubmed ID
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31357522
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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