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Title
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Six-month results of selective bladder denervation in women with refractory overactive bladder
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Author
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Abstract
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| Purpose:We report 6-month efficacy and safety outcomes of selective bladder denervation in women with refractory overactive bladder.Materials and Methods:Women with refractory overactive bladder and urgency urinary incontinence were enrolled in 2 prospective feasibility studies with the same entry criteria. They underwent selective bladder denervation of the subtrigonal region containing afferent sensory nerves. Patients were followed for 6 months and assessed for adverse events, overactive bladder symptoms and health related quality of life measures.Results:In the 35 women with a mean age of 66 years who were enrolled in the study all selective bladder denervation procedures were completed successfully. During 6 months of followup the symptom improvement based on 3-day bladder diaries was 59% for urgency urinary incontinence (p <0.001), 59% for urinary incontinence (p <0.001), 39% for urgency (p <0.001), 9% for urinary frequency (p = 0.01) and 27% for the total urgency and frequency score (p <0.001). Most of this treatment benefit was realized in the first month. The rate of clinical success, defined as a 50% or greater reduction in urgency urinary incontinence, was 70%, treatment benefit was reported in 75% of patients and the dry/cure rate was 27%. Statistically significant improvements during 6 months were identified on the symptom bother and health related quality of life scales on the OAB-q (Overactive Bladder Questionnaire) and on all KHQ (King's Health Questionnaire) domains except general health perception. Device or procedure related adverse events were reported in 6 patients (17%).Conclusions:Pooled results of 2 prospective feasibility studies suggest that selective bladder denervation is a promising minimally invasive treatment option in women with refractory overactive bladder. |
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Language
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English
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Source (journal)
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The journal of urology. - Baltimore, Md
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Publication
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Baltimore, Md
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2019
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ISSN
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0022-5347
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DOI
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10.1016/J.JURO.2018.09.043
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Volume/pages
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201
:3
(2019)
, p. 573-579
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ISI
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000475762000044
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Pubmed ID
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30240691
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Full text (Publisher's DOI)
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