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Title
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One-year results with selective bladder denervation in women with refractory overactive bladder
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Author
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Abstract
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| Aims: To report 1-year results with selective bladder denervation (SBD) of the trigone in women with refractory overactive bladder (OAB). Methods: In this prospective, international, multicenter case series, women with refractory OAB underwent a single SBD treatment of the bladder subtrigone region using temperature-controlled radiofrequency. Patients were followed for 1 year and evaluated for changes in OAB symptoms and adverse events. Results: Among 35 women, 29 (83%) returned for 1-year follow up. Median symptom reductions based on 3-day bladder diaries were 68% for urgency urinary incontinence (P < .001), 67% for urinary incontinence (P < .001), 43% for urgency episodes (P < .001), 5% for urinary frequency (P = .19), and 33% for the total urgency and frequency score (P < .001), with the majority of treatment benefit realized in the first month. Treatment benefit was reported in 72% of patients, the clinical success rate (>= 50% reduction in urgency urinary incontinence) was 69%, and the dry rate was 10%. Statistically significant improvements occurred on Symptom Bother and Health-related Quality of Life scales on the Overactive Bladder questionnaire, and on 6 of 9 King's Health Questionnaire domains. Patients with less severe baseline symptoms had similar quality of life improvements as those with more severe baseline symptoms. Device- or procedure-related adverse events were reported in 6 (17%) patients. Conclusions: A single treatment with selective bladder denervation is durable for 1-year in a significant proportion of women with refractory overactive bladder. |
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Language
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English
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Source (journal)
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Neurourology and urodynamics. - New York
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Publication
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Hoboken
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Wiley
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2019
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ISSN
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0733-2467
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DOI
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10.1002/NAU.24110
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Volume/pages
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7 p.
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ISI
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000479536200001
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Pubmed ID
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31359508
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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