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Title
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Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy
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Author
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Abstract
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| Background Acute and late toxicity after intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC) impacts on patient quality of life; yet, very late toxicity data remain scarce. This study assessed dysphagia, xerostomia, and neck fibrosis 3-8 years after IMRT. Methods A retrospective analysis using generalized estimated equations was performed on 60 patients with HNC treated with fractionated IMRT between 2000 and 2015 who had a follow-up >= 8 years. Toxicity was scored using LENT-SOMA scales. Results A trend towards a nonlinear global time effect (P = .05) was noted for dysphagia with a decrease during the 5 years post-treatment and an increase thereafter. A significant decrease in xerostomia (P = .001) and an increase in neck fibrosis (P = .04) was observed until 8 years. Conclusions Dysphagia, xerostomia, and neck fibrosis do not appear stable over time and remain highly prevalent in the very late follow-up. Our findings support the need for prospective trials investigating very late toxicity in patients with HNC. |
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Language
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English
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Source (journal)
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Head and neck: journal for the sciences and specialties of the head and neck. - New York, N.Y.
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NECK
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Publication
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Hoboken
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Wiley
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2019
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ISSN
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1043-3074
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DOI
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10.1002/HED.25880
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Volume/pages
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10 p.
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ISI
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000477315400001
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Pubmed ID
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31329343
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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