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Title
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Catalytic asymmetric synthesis of diketopiperazines by intramolecular Tsuji–Trost allylation
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Author
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Abstract
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| We report the intramolecular Tsuji–Trost reaction of Ugi adducts to give spiro-diketopiperazines in high yield and with high enantioselectivity. This approach allows the catalytic asymmetric construction of a broad range of these medicinally important heterocycles under mild conditions, in two steps from cheap, commercially available starting materials. |
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Language
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English
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Source (journal)
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The journal of organic chemistry. - Washington, D.C., 1936, currens
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Publication
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Washington, D.C.
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2019
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ISSN
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0022-3263
[print]
1520-6904
[online]
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DOI
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10.1021/ACS.JOC.9B01994
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Volume/pages
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84
:18
(2019)
, p. 12058-12070
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ISI
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000487576900065
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Pubmed ID
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31446758
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Full text (Publisher's DOI)
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Full text (open access)
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