|
Title
|
|
|
|
C9orf72 repeats compromise nucleocytoplasmic transport
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| The molecular mechanisms of neurodegeneration due to a repeat expansion in C9orf72, the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, are unknown. Three reports now link compromised nucleocytoplasmic transport to disease pathogenesis. Whether RNA structures or dipeptide repeat proteins are most toxic in humans remains open to question. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Nature reviews : neurology
|
|
|
Publication
|
|
|
|
New york
:
Nature publishing group
,
2015
|
|
|
ISSN
|
|
|
|
1759-4758
1759-4766
|
|
|
DOI
|
|
|
|
10.1038/NRNEUROL.2015.219
|
|
|
Volume/pages
|
|
|
|
11
:12
(2015)
, 2 p.
|
|
|
ISI
|
|
|
|
000367746100002
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|