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Title
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Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS
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Author
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Abstract
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| The nuclear protein fused in sarcoma (FUS) is found in cytoplasmic inclusions in a subset of patients with the neurodegenerative disorder frontotemporal lobar degeneration (FTLD-FUS). FUS contains a methylated arginine-glycine-glycine domain that is required for transport into the nucleus. Recent findings have shown that this domain is hypomethylated in patients with FTLD-FUS. To determine whether the cause of hypomethylation is the result of mutations in protein N-arginine methyltransferases (PRMTs), we selected 3 candidate genes (PRMT1, PRMT3, and PRMT8) and performed complete sequencing analysis and real-time polymerase chain reaction mRNA expression analysis in 20 FTLD-FUS cases. No mutations or statistically significant changes in expression were observed in our patient samples, suggesting that defects in PRMTs are not the cause of FTLD-FUS. (C) 2013 Elsevier Inc. All rights reserved. |
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Language
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English
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Source (journal)
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Neurobiology of aging. - Fayetteville, N.Y.
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Publication
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Fayetteville, N.Y.
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2013
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ISSN
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0197-4580
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DOI
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10.1016/J.NEUROBIOLAGING.2013.04.004
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Volume/pages
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34
:9
(2013)
, 3 p.
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Article Reference
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UNSP 2235.e11
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ISI
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000320997300023
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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