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Title
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MRS in Early and Presymptomatic Carriers of a Novel Octapeptide Repeat Insertion in the Prion Protein Gene
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Author
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Abstract
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| To evaluate the proton magnetic resonance (MR) spectroscopy (H-1 MRS) changes in carriers of a novel octapeptide repeat insertion in the prion protein gene (PRNP) and family history of frontotemporal dementia with ataxia. Four at-risk mutation carriers and 13 controls were compared using single voxel, short TE, H-1 MRS from the posterior cingulate gyrus. The mutation carriers had an increased choline/creatine, P= .003 and increased myoinositol/creatine ratio, P= .003. H-1 MRS identified differences in markers of glial activity and choline metabolism in pre- and early-symptomatic carriers of a novel PRNP gene octapeptide insertion. These findings expand the possible diagnostic utility of H-1 MRS in familial prion disorders. |
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Language
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English
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Source (journal)
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Journal of neuroimaging. - Boston, Mass.
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Publication
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Boston, Mass.
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2013
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ISSN
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1051-2284
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DOI
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10.1111/J.1552-6569.2012.00717.X
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Volume/pages
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23
:3
(2013)
, p. 409-413
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ISI
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000321213500016
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Full text (Publisher's DOI)
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