|
Title
|
|
|
|
HPV testing on vaginal/cervical nurse-assisted self-samples versus clinician-taken specimens and the HPV prevalence, in Adama Town, Ethiopia
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| This study aimed to determine the feasibility of vaginal/cervical nurse-assisted self-sampling (NASS) and the agreement between human papilloma virus (HPV) tests on self-samples versus clinician-taken (CT) specimens. Women participated voluntarily for cervical cancer screening at St. Aklesia Memorial Hospital. Eighty-three women provided a total of 166 coupled self-taken and CT specimens collected. Specimens were stored at room temperature for a maximum of 10 months and analyzed using validated the RIATOL qPCR HPV genotyping test, a quantitative polymerase chain reaction (qPCR) highthroughput HPV E6, E7 assay. The average age of the participating women was 32 years. Seventy-three women (87.9%) felt that NASS was easy to use. An overall HPV, high-risk (HR) HPV, and low-risk HPV prevalence was 22.7% (15/66), 18.2% (12/66), and 6.1% (4/66), respectively. The overall HR HPV prevalence was 17.2% (NASS) and 15.5% (CT). The most prevalent HPV type was HPV51; HPV 16 was only detected in 1 woman (CT+ NASS) and HPV18 only in 1 woman (CT). The overall measurement agreement between self-taken and CT samples was moderate with a kappa value of 0.576 (P<. 001). Lifetime partnered with > 2 men were associated with HR HPV positivity (P<. 001). There was a strong statistical association between HR HPV positivity and visual inspection with acetic acid-positive (P<. 001). The NASS for HPV testing could be seen as an alternative option and might be acceptable to Ethiopian women. The overall HR HPV prevalence was comparable with Sub-Saharan countries in the general population. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Medicine: analytical reviews of internal medicine, dermatology, neurology, pediatrics and psychiatry. - Baltimore, Md
| |
|
Publication
|
|
|
|
Baltimore, Md
:
2019
| |
|
ISSN
|
|
|
|
0025-7974
1536-5964
| |
|
DOI
|
|
|
|
10.1097/MD.0000000000016970
| |
|
Volume/pages
|
|
|
|
98
:35
(2019)
, 8 p.
| |
|
Article Reference
|
|
|
|
e16970
| |
|
ISI
|
|
|
|
000486239900053
| |
|
Pubmed ID
|
|
|
|
31464941
| |
|
Medium
|
|
|
|
E-only publicatie
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (open access)
|
|
|
|
| |
|