Estimating retinal blood flow velocities by optical coherence tomography

Seidel, Gerald; Aschinger, Gerold; Singer, Christoph; Herzog, Sereina Annik; Weger, Martin; Haas, Anton; Werkmeister, Rene Marcel; Schmetterer, Leopold; Garhoefer, Gerhard

doi:10.1001/JAMAOPHTHALMOL.2016.2507

Title

Estimating retinal blood flow velocities by optical coherence tomography

Author

Seidel, Gerald

Aschinger, Gerold

Singer, Christoph

Herzog, Sereina Annik

Weger, Martin

Haas, Anton

Werkmeister, Rene Marcel

Schmetterer, Leopold

Garhoefer, Gerhard

Abstract

IMPORTANCE While optical coherence tomography (OCT) angiography has been considered to evaluate retinal capillary blood flow instead of fluorescein angiography, the reflectance pattern of blood vessels on structural OCT might also provide retinal capillary flow data in the absence of fluorescein angiography. This potential has been insufficiently explored, despite promising data concerning a possible relationship between the reflectance pattern of blood vessels and their perfusion velocity in a laboratory setting. OBJECTIVE To evaluate the potential of retinal blood flow velocity estimation by structural OCT. DESIGN, SETTING, AND PARTICIPANTS Cross-sectional observational study conducted from June to November 2015 at a tertiary clinical referral center. Sixty arteries (the superior and inferior temporal arteries) from 30 eyes of 30 patients (17 female, 13 male) were included in the study. MAIN OUTCOMES AND MEASURES Based on the intraluminal contrast patterns of retinal arteries on OCT, 3 independent graders categorized the blood flow velocities as low, medium, or high. These results and the results from a software-based intraluminal contrast analysis were compared with the retinal blood flow velocities measured by video fluorescein angiography. RESULTS Among the 30 eyes of 30 patients (mean [SD] age, 72.6 [12.3] years; 17 female, 13 male), 15 were controls without retinal occlusion, 6 had a branch retinal artery occlusion, and 9 had a central retinal artery occlusion. When discriminating between low flow velocities and medium or high flow velocities, the graders' sensitivity ranged from 88.2% to 100% (grader 1: 88.2%; 95% CI, 63.6%-98.5%; grader 2: 88.2%; 95% CI, 63.6%-98.5%; and grader 3: 100%; 95% CI, 69.8%-100%) and their specificity ranged from 97.6% to 100% (grader 1: 100%; 95% CI, 87.7%-100%; grader 2: 97.6%; 95% CI, 87.4%-99.9%; and grader 3: 100%; 95% CI, 87.7%-100%). The. coefficients of the comparison between the 3 graders and the angiography were 0.77 (95% CI, 0.60-0.93; P <.001), 0.64 (95% CI, 0.44-0.83; P <.001), and 0.87 (95% CI, 0.74-0.99; P <.001). In the computer-based assessment, the contrast reduction of the intraluminal pattern could be numerically expressed in a specific coefficient in the model (I-2, describing the angular change of the backscattering intensity in the model), which presented nonoverlapping intervals between low flow velocities and medium or high flow velocities (mean [SD] I2, 0.3 [5.3], 20.4 [6.4], and 21.7 [4.0], respectively). CONCLUSIONS AND RELEVANCE This study suggests that a low retinal blood flow velocity reflects in a visually distinct contrast reduction of the intraluminal pattern of retinal vessels on OCT. Larger studies are required to assess the clinical benefits.

Language

English

Source (journal)

JAMA ophthalmology / AMA. - Chicago, Ill., 2013, currens

Publication

Chicago, Ill. : 2016

ISSN

2168-6165 [print]

2168-6173 [online]

DOI

10.1001/JAMAOPHTHALMOL.2016.2507

Volume/pages