Title
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Circadian macular volume changes in the healthy human choroid
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Author
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Abstract
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PURPOSE: To investigate a potential circadian fluctuation of the choroidal volume in healthy adults by enhanced depth imaging (EDI) via spectral-domain optical coherence tomography (SD OCT). DESIGN: Prospective observational case series. METHODS: Thirty healthy eyes of 15 healthy subjects with a median age of 26 years (range 22-55) underwent EDI SD OCT scans for macular choroidal volume measurement every 3 hours within a 24-hour period at a single tertiary center. The mean ocular perfusion pressure was calculated for each eye at each of the 8 time points as 2/3 (mean arterial pressure-intraocular pressure [IOP]). The circadian fluctuation of the macular choroidal volume as well as the association with axial length, mean ocular perfusion pressure, or IOP was assessed using a linear mixed model. RESULTS: Macular choroidal volume showed a significant circadian fluctuation (P <.05) and was lowest at midday (mean +/- SD, 10.14 +/- 2.62 mm(3)) and highest at 3 AM (mean +/- SD, 10.66 +/- 2.70 mm(3)). Of all factors tested, only mean ocular perfusion pressure showed a significant association with macular choroidal volume fluctuation (P = .016). CONCLUSIONS: Macular choroidal volume shows a significant circadian pattern with higher values at night and lower values during the day in young adults. Besides time, mean ocular perfusion pressure is significantly associated with this fluctuation. (C) 2015 by Elsevier Inc. All rights reserved. |
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Language
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English
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Source (journal)
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American journal of ophthalmology. - Chicago, Ill.
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Publication
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Chicago, Ill.
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2015
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ISSN
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0002-9394
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DOI
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10.1016/J.AJO.2014.11.002
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Volume/pages
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159
:2
(2015)
, p. 365-371
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ISI
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000348634300019
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Full text (Publisher's DOI)
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