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Title
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Tryptophan metabolism in inflammaging : from biomarker to therapeutic target
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Author
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Abstract
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| Inflammation aims to restore tissue homeostasis after injury or infection. Age-related decline of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype known as inflammaging that is involved in many age-related diseases. Activation of tryptophan (Trp) metabolism along the kynurenine (Kyn) pathway prevents hyperinflammation and induces long-term immune tolerance. Systemic Trp and Kyn levels change upon aging and in age-related diseases. Moreover, modulation of Trp metabolism can either aggravate or prevent inflammaging-related diseases. In this review, we discuss how age-related Kyn/Trp activation is necessary to control inflammaging and alters the functioning of other metabolic faiths of Trp including Kyn metabolites, microbiota-derived indoles and nicotinamide adenine dinucleotide (NAD(+)). We explore the potential of the Kyn/Trp ratio as a biomarker of inflammaging and discuss how intervening in Trp metabolism might extend health- and lifespan. |
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Language
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English
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Source (journal)
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Frontiers in immunology. - Place of publication unknown
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Publication
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Lausanne
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Frontiers media sa
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2019
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ISSN
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1664-3224
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DOI
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10.3389/FIMMU.2019.02565
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Volume/pages
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10
(2019)
, 8 p.
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Article Reference
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2565
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ISI
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000496159500001
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Pubmed ID
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31736978
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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