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Title
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High-dose growth hormone treatment of short children born small for gestational age
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Author
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Abstract
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| The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg. At the start of the study, mean age was 5.2 yr, bone age was 4.0 yr, height sos was -3.5, height velocity sos was -0.8, weight SDS was -2.7, and body mass index SDS was -1.9. Catch-up growth was observed in none of the untreated and all of the treated children. The response to GH treatment included a near doubling of growth velocity and of weight gain and a mean height increment of more than 2 SDS. GH treatment was associated with a distinct acceleration of bone maturation. The differences between the growth responses evoked by the two GH doses were minor. The prepubertal GH-induced catch-up growth was associated with elevated serum concentrations of insulin, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and osteocalcin, whereas insulin-like growth factor-II levels remained unaltered. GH treatment was well tolerated. In conclusion, high-dose GH administration over 2 yr is emerging as a potential therapy to increase the short stature that results from insufficient catch-up growth in young children born small for gestational age. The long-term impact of this approach remains to be delineated. |
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Language
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English
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Source (journal)
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The journal of clinical endocrinology and metabolism. - Baltimore, Md
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Publication
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Baltimore, Md
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1996
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ISSN
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0021-972X
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DOI
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10.1210/JC.81.5.1887
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Volume/pages
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81
:5
(1996)
, p. 1887-1892
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ISI
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A1996UK19800041
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Full text (Publisher's DOI)
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