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Title
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The seroprevalence of cytomegalovirus infection in Belgium anno 2002 and 2006 : a comparative analysis with hepatitis A virus seroprevalence
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Author
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Abstract
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| Cytomegalovirus (CMV) infection is endemic worldwide but its seroprevalence varies widely. The goal of this study was to estimate the age-specific seroprevalence of CMV infection in Belgium based on two cross-sectional serological datasets from 2002 and 2006. The seroprevalence was estimated relying on diagnostic test results based on cut-off values pre-specified by the manufacturers of the tests as well as relying on mixture models applied to continuous pathogen-specific immunoglobulin G antibody titre concentrations. The age-specific seroprevalence of hepatitis A virus (HAV), based on three Belgian cross-sectional serological datasets from 1993, 2002 and 2006, was used as a comparator since individuals acquire lifelong immunity upon recovery, implying an increasing seroprevalence with age. The age group weighted overall CMV seroprevalence derived from the mixture model was 32% (95% confidence interval (CI) 31-34%) in 2002 and 31% (95% CI 30-32%) in 2006. We demonstrated that CMV epidemiology differs from the immunizing infection HAV. This was the first large-scale study of CMV and HAV serial datasets in Belgium, estimating seroprevalence specified by age and birth cohort. |
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Language
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English
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Source (journal)
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Epidemiology and infection. - London, 1987, currens
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Publication
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London
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2019
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ISSN
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0950-2688
[print]
1469-4409
[online]
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DOI
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10.1017/S0950268819000487
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Volume/pages
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147
(2019)
, p. 1-9
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ISI
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000475912200085
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Pubmed ID
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31063104
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Full text (Publisher's DOI)
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Full text (open access)
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