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Title
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Serum specific IgE antibodies in immediate drug hypersensitivity
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Author
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Abstract
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| Immediate drug hypersensitivity reactions (IDHRs) constitute a significant health problem that may be compounded by consequences of diagnostic error. In daily practice, IDHR diagnostic work up starts with drug-specific skin testing and/or quantification of specific IgE (sigE) antibodies in serum. Here we critically review the performance, i.e. potential and limitations of sIgE to β-lactam antibiotics (β-LABs), curarizing neuromuscular blocking agents (NMBAs), opiates and (semi)synthetic opioids, fluoroquinolones (FQs), poppy seed (papaver somniferum), chlorhexidine and finally Hevea latex. Quintessence of these studies is clear. Quantification of these drug-specific sIgE should not be used in isolation to document or exclude diagnosis of an IDHR. False negative results entail the risk for subsequent potentially life-threatening anaphylaxis upon re-exposure. False positive results lead to erroneous avoidance and unnecessary substitutions and fails to identify the true etiology. |
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Language
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English
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Source (journal)
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Clinica chimica acta. - Amsterdam, 1956, currens
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Publication
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Amsterdam
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Elsevier
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2020
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ISSN
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0009-8981
[print]
1873-3492
[online]
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DOI
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10.1016/J.CCA.2020.02.005
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Volume/pages
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504
(2020)
, p. 119-124
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ISI
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000521514600016
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Pubmed ID
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32035852
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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