Publication
Title
Combining designer receptors exclusively activated by designer drugs and neuroimaging in experimental models : a powerful approach towards neurotheranostic applications
Author
Abstract
The combination of chemogenetics targeting specific brain cell populations with in vivo imaging techniques provides scientists with a powerful new tool to study functional neural networks at the whole-brain scale. A number of recent studies indicate the potential of this approach to increase our understanding of brain function in health and disease. In this review, we discuss the employment of a specific chemogenetic tool, designer receptors exclusively activated by designer drugs, in conjunction with non-invasive neuroimaging techniques such as PET and MRI. We highlight the utility of using this multiscale approach in longitudinal studies and its ability to identify novel brain circuits relevant to behaviour that can be monitored in parallel. In addition, some identified shortcomings in this technique and more recent efforts to overcome them are also presented. Finally, we discuss the translational potential of designer receptors exclusively activated by designer drugs in neuroimaging and the promise it holds for future neurotheranostic applications.
Language
English
Source (journal)
British journal of pharmacology. - London
Publication
Hoboken : Wiley , 2020
ISSN
0007-1188
DOI
10.1111/BPH.14885
Volume/pages
p. 1-28 , 11 p.
ISI
000510581800001
Pubmed ID
31658365
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Spatial neglect in rodents: a model for studying neuroplasticity at the network level.
Cholinergic and noradrenergic modulation of memory and mood.
Multimodal Imaging of cholinergic neuromodulation during specific memory phases in the rodent brain.
Cholinergic and noradrenergic neuromodulation of memory and mood.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 04.03.2020
Last edited 02.10.2024
To cite this reference