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Title
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Oocyte maturation under lipotoxic conditions induces carryover transcriptomic and functional alterations during post-hatching development of good-quality blastocysts : novel insights from a bovine embryo-transfer model
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Author
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Abstract
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| STUDY QUESTION: Does oocyte maturation under lipolytic conditions have detrimental carry-over effects on post-hatching embryo development of good-quality blastocysts after transfer? SUMMARY ANSWER: Surviving, morphologically normal blastocysts derived from bovine oocytes that matured under lipotoxic conditions exhibit long-lasting cellular dysfunction at the transcriptomic and metabolic levels, which coincides with retarded post-hatching embryo development. |
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Language
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English
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Source (journal)
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Human reproduction. - Bonn
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Publication
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Bonn
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2020
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ISSN
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0268-1161
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DOI
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10.1093/HUMREP/DEZ248
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Volume/pages
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35
:2
(2020)
, p. 293-307
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ISI
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000522648000005
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Pubmed ID
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32112081
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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