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Title
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Accessory cells for β-cell transplantation
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Author
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Abstract
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| Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes mellitus with persistent risk of glycaemic alterations and life-threatening complications. Restoration of the endogenous beta-cell mass through regeneration or transplantation offers an attractive alternative. Unfortunately, signals that drive beta-cell regeneration remain enigmatic and beta-cell replacement therapy still faces major hurdles that prevent its widespread application. Co-transplantation of accessory non-islet cells with islet cells has been shown to improve the outcome of experimental islet transplantation. This review will highlight current travails in beta-cell therapy and focuses on the potential benefits of accessory cells for islet transplantation in diabetes. |
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Language
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English
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Source (journal)
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Diabetes, obesity & metabolism. - Oxford, 1999, currens
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Publication
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Oxford
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Blackwell
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2015
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ISSN
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1462-8902
[print]
1463-1326
[online]
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DOI
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10.1111/DOM.12556
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Volume/pages
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18
:2
(2016)
, p. 115-124
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ISI
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000368626300001
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Full text (Publisher's DOI)
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