|
Title
|
|
|
|
Identification of epitope-specific T cells in T-cell receptor repertoires
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| Recognition of cancer epitopes by T cells is fundamental for the activation of targeted antitumor responses. As such, the identification and study of epitope-specific T cells has been instrumental in our understanding of cancer immunology and the development of personalized immunotherapies. To facilitate the study of T-cell epitope specificity, we developed a prediction tool, TCRex, that can identify epitope-specific T-cell receptors (TCRs) directly from TCR repertoire data and perform epitope-specificity enrichment analyses. This chapter details the use of the TCRex web tool. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Methods in molecular biology. - Totowa, N.J., 1984, currens
|
|
|
Source (book)
|
|
|
|
Bioinformatics for cancer immunotherapy : methods and protocols
|
|
|
Source (series)
|
|
|
|
Methods in molecular biology (MIMB) ; 2120
|
|
|
Publication
|
|
|
|
New York, N.Y.
:
Humana
,
2020
|
|
|
ISSN
|
|
|
|
1064-3745
|
|
|
ISBN
|
|
|
|
978-1-0716-0326-0
978-1-0716-0327-7
|
|
|
DOI
|
|
|
|
10.1007/978-1-0716-0327-7_13
|
|
|
Volume/pages
|
|
|
|
p. 183-195
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|