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Title
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Activation-induced surface proteins in the identification of antigen-responsive CD4 T cells
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Author
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Abstract
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| Identification of antigen specificity of CD4 T cells is instrumental in understanding adaptive immune responses in health and disease. The high diversity of CD4 T cell repertoire combined with the functional heterogeneity of the compartment poses a challenge to the assessment of CD4 T cell responses. In spite of that, multiple technologies allow direct or indirect interrogation of antigen specificity of CD4 T cells. In the last decade, multiple surface proteins have been established as cytokine-independent surrogates of in vitro CD4 T cell activation, and have found applications in the live identification and isolation of antigen-responsive CD4 T cells. Here we review the current knowledge of the surface proteins that permit identification of viable antigen-responsive CD4 T cells with high specificity, including those capable of identifying specialized CD4 T subsets such as germinal center follicular helper T cells and CD4 regulatory T cells. |
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Language
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English
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Source (journal)
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Immunology letters. - Amsterdam
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Publication
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Amsterdam
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Elsevier
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2020
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ISSN
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0165-2478
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DOI
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10.1016/J.IMLET.2019.12.006
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Volume/pages
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219
(2020)
, p. 1-7
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ISI
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000514252300001
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Pubmed ID
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31881234
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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