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Title
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Cost of inappropriate antimicrobial use for upper respiratory infection in Japan
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Author
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Abstract
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| Background Antibiotics are often prescribed inappropriately to patients with upper respiratory infection (URI) in ambulatory care settings; however, the economic burden of such prescription has not been quantitatively assessed. Here, we aimed to evaluate the additional cost of antimicrobial prescription for URI at the population level in Japan. Methods We conducted a retrospective observational survey using longitudinal claims data between 2013 and 2016 obtained from JMDC Claims Database, which contains data from 5 center dot 1 million corporate employees and family members under the age of 65 years. Appropriateness of antibiotic prescription was assessed by a panel of six infectious disease physicians according to ICD-10 code in JMDC Claims Database. Total additional cost of antibiotic prescription for URI at the national level was estimated by weighting of age-structured population data. Results The annual additional cost of inappropriate antibiotic prescription for URI was estimated at 423 center dot 6 (95% CI: 416 center dot 8-430 center dot 5) million USD in 2013, 340 center dot 9 (95% CI: 335 center dot 7-346 center dot 2) million USD in 2014, 349 center dot 9 (95% CI: 344 center dot 5-355 center dot 3) million USD in 2015, and 297 center dot 1 (95% CI: 292 center dot 4-301 center dot 9) million USD in 2016. Three classes of broad-spectrum oral antibiotics (third-generation cephalosporins, macrolides, and fluoroquinolones) accounted for > 90% of the total additional cost. Conclusions Although a decreasing trend was observed, annual additional costs of inappropriate antibiotic prescriptions for URI could be a substantial economic burden in Japan. Appropriately prescribing broad-spectrum oral antibiotics might be an important issue to reduce unnecessary medical costs in Japanese ambulatory care. |
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Language
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English
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Source (journal)
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BMC health services research. - London
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Publication
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London
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2020
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ISSN
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1472-6963
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DOI
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10.1186/S12913-020-5021-1
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Volume/pages
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20
:1
(2020)
, p. 1-8
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Article Reference
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153
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ISI
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000518633500001
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Pubmed ID
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32111202
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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