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Title
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Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness
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Author
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Abstract
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| Objective To test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress-sensitivity measures. Methods The data were retrieved from a general population twin cohort including 593 adolescents and young adults. Childhood adversity was assessed using the Childhood Trauma Questionnaire. Daily-life stressors and momentary mental state domains were measured using ecological momentary assessment. PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis. The analyses were conducted using multilevel mixed-effects tobit regression models. Results Both childhood adversity and daily-life stressors were associated with increased negative affect, decreased positive affect, and increased subtle psychosis expression, while PRS-S was only associated with increased positive affect. No gene-environment correlation was detected. There is novel evidence for interaction effects between PRS-S and childhood adversity to influence momentary mental states [negative affect (b = 0.07, P = 0.013), positive affect (b = -0.05, P = 0.043), and subtle psychosis expression (b = 0.11, P = 0.007)] and stress-sensitivity measures. Conclusion Exposure to childhood adversities, particularly in individuals with high PRS-S, is pleiotropically associated with emotion dysregulation and psychosis proneness. |
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Language
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English
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Source (journal)
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Acta psychiatrica Scandinavica. - Copenhagen
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Publication
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Hoboken
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Wiley
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2020
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ISSN
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0001-690X
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DOI
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10.1111/ACPS.13158
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Volume/pages
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p. 1-11
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ISI
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000514655300001
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Pubmed ID
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32027017
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Full text (Publisher's DOI)
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Full text (open access)
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