Publication
Title
The role of endothelial miRNAs in myocardial biology and disease
Author
Abstract
The myocardium is a highly structured pluricellular tissue which is governed by an intricate network of intercellular communication. Endothelial cells are the most abundant cell type in the myocardium and exert crucial roles in both healthy myocardium and during myocardial disease. In the last decade, microRNAs have emerged as new actors in the regulation of cellular function in almost every cell type. Here, we review recent evidence on the regulatory function of different microRNAs expressed in endothelial cells, also called endothelial microRNAs, in healthy and diseased myocardium. Endothelial microRNA emerged as modulators of angiogenesis in the myocardium, they are implicated in the paracrine role of endothelial cells in regulating cardiac contractility and homeostasis, and interfere in the crosstalk between endothelial cells and cardiomyocytes.
Language
English
Source (journal)
Journal of molecular and cellular cardiology. - London
Publication
Oxford : Elsevier sci ltd , 2020
ISSN
0022-2828
DOI
10.1016/J.YJMCC.2019.11.151
Volume/pages
138 (2020) , p. 75-87
ISI
000517348700008
Pubmed ID
31756323
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Identification of small molecule ErbB4 agonists for treatment of heart failure.
Activating the neuregulin-1/ErbB4 pathway for treatment of heart failure.
Studies of the ErbB4 receptor in myocardial non-myocytes to create new opportunities for the treatment of cardiac disease.
Identification of small molecule ErbB4 agonist for treatment of heart failure, diabetic kidney injury and fibrotic disorders.
Diagnostic and therapeutic potential of microRNA-181c in HFpEF.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 06.04.2020
Last edited 02.12.2024
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