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Title
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A novel electrocardiographic index for the diagnosis of diastolic dysfunction
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Author
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Abstract
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| Background: Although the assessment of diastolic dysfunction (DD) is an integral part of routine cardiologic examinations, little is known about associated electrocardiographic (ECG) changes. Our aim was to investigate a potential role of ECG indices for the recognition of patients with DD. Methods and Results: ECG parameters correlating with echocardiographic findings of DD were retrospectively assessed in a derivation group of 172 individuals (83 controls with normal diastolic function, 89 patients with DD) and their diagnostic performance was tested in a validation group of 50 controls and 50 patients. The patient group with a DD Grade 1 and 2 showed longer QTc (422 +/- 24ms and 434 +/- 32ms vs. 409 +/- 25ms, p<0.0005) and shorter Tend-P and Tend-Q intervals, reflecting the electrical and mechanical diastole (240 +/- 78ms and 276 +/- 108ms vs. 373 +/- 110ms, p<0.0001; 409 +/- 85ms and 447 +/- 115ms vs. 526 +/- 119ms, p<0.0001). The PQ-interval was significantly longer in the patient group (169 +/- 28ms and 171 +/- 38ms vs. 153 +/- 22ms, p<0.005). After adjusting for possible confounders, a novel index (Tend-P/[PQxAge]) showed a high performance for the recognition of DD, stayed robust in the validation group (sensitivity 82%, specificity 93%, positive predictive value 93%, negative predictive value 82%, accuracy 88%) and proved a substantial added value when combined with the indexed left atrial volume (LAESVI, sensitivity 90%, specificity 92%, positive predictive value 95%, negative predictive value 86%, accuracy 91%). Conclusions: A novel electrocardiographic index Tend-P/(PQxAge) demonstrates a high diagnostic accuracy for the diagnosis of DD and yields a substantial added value when combined with the LAESVI. |
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Language
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English
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Source (journal)
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PLoS ONE
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Publication
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2013
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ISSN
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1932-6203
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DOI
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10.1371/JOURNAL.PONE.0079152
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Volume/pages
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8
:11
(2013)
, 10 p.
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Article Reference
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UNSP e79152
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ISI
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000326597400048
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Pubmed ID
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24223898
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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