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Title
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Ajmaline challenge in young individuals with suspected Brugada syndrome
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Author
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Abstract
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| Methods: Among a larger series of patients included in the BS database of our Department, 179 patients undergoing ajmaline challenge were included in the study and categorized in two groups according to age: group 1 (< 18 years old) and group 2 (>= 18 years old). Clinical features and results of the ajmaline challenge of each group were compared. Results: Young individuals were more often asymptomatic compared to adult patients (P = 0.002). They showed a higher number of normal ECGs (P = 0.023), a lower percentage of Brugada type II electrocardiographic pattern compared to the adult population (P = 0.011), and a comparable amount of spontaneous Brugada type III electrocardiographic pattern (P = 0.695). Ajmaline provoked a higher degree of intraventricular conduction delay (P = 0.002) and higher degree of prolongation of the ventricular repolarization phase (P = 0.013) in young individuals but its pro-arrhythmic risk was comparable in the two groups (P = 0.684). Furthermore, inducibility of ventricular arrhythmias in young patients with a positive ajmaline test was comparable to that of the adults with a positive ajmaline test (P = 0.694). Conclusions: The present study demonstrates the low-risk profile of the ajmaline test in young patients when performed by experienced physicians and nurses in an appropriate environment. (PACE 2011; 1-6). |
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Language
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English
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Source (journal)
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Pacing and clinical electrophysiology. - Mount Kisco, N.Y., 1978, currens
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Publication
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Mount Kisco, N.Y.
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2011
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ISSN
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0147-8389
[print]
1540-8159
[online]
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DOI
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10.1111/J.1540-8159.2011.03033.X
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Volume/pages
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34
:6
(2011)
, p. 736-741
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ISI
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000291395000017
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Pubmed ID
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21303388
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Full text (Publisher's DOI)
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