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Title
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Number of electrocardiogram leads displaying the diagnostic coved-type pattern in Brugada syndrome : a diagnostic consensus criterion to be revised
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Author
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Abstract
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| According to the diagnostic consensus criteria, the electrocardiographic (ECG) diagnosis of Brugada syndrome requires coved-type >= 2 mm ST-segment elevation in > 1 right precordial lead (RPL) V1-V3 in the presence or absence of a sodium-channel blocker. However, this consensus has not been evaluated. We aimed to assess the distribution of coved-type ST-segment elevation on RPLs in a large patient cohort to reevaluate the appropriateness of the diagnostic consensus criteria. We included 186 individuals with spontaneous and/or drug-induced ECGs of coved-type >= 2 mm ST-segment elevation in at least one RPL. A total of 376 ECGs were analysed for the number, distribution and maximal J-point elevation of diagnostic RPLs. Among all ECGs, 27 (7%) showed a coved-type pattern in 3 RPLs, 205 (55%) in 2 RPLs, and 144 (38%) in only 1 RPL. Leads V1 and V2 were diagnostic in 99% of all ECGs with two diagnostic RPLs. Lead V3 alone was not diagnostic in any ECG. Maximal J-point elevation was significantly higher in lead V2 than V1. Sixty case subjects (32%) had only ECGs with one RPL displaying a coved-type ST-segment elevation. There was no significant difference in clinical presentation and outcome compared with the 126 Brugada patients with ECGs displaying > 1 diagnostic RPL. Major arrhythmic events occurred with the same rate (8%) in both groups during a follow-up > 5 years. Lead V3 does not yield diagnostic information in Brugada syndrome. Individuals with ECGs displaying only one diagnostic RPL have a similar clinical profile and arrhythmic risk as Brugada patients with ECGs displaying > 1 diagnostic RPL. Revision of the consensus criteria should be considered. |
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Language
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English
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Source (journal)
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European heart journal. - London
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Publication
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London
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2010
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ISSN
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0195-668X
[Print]
1522-9645
[Online]
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DOI
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10.1093/EURHEARTJ/EHQ049
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Volume/pages
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31
:11
(2010)
, p. 1357-1364
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ISI
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000278436400018
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Pubmed ID
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20233789
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Full text (Publisher's DOI)
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