|
Title
|
|
|
|
Inferior and lateral electrocardiographic repolarization abnormalities in Brugada syndrome
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Background-Repolarization abnormalities in the inferior-lateral leads in Brugada syndrome (BS) have not been systematically investigated. Methods and Results-280 patients (age, 41 +/- 18 years; 168 males) with BS were screened for inferior-lateral repolarization abnormalities. The repolarization abnormalities were classified either as early repolarization pattern or coved >= 2-mm Brugada pattern and as spontaneous or class I antiarrhythmic drug (AAD) induced. Thirty-two patients (11%) had inferior-lateral spontaneous early repolarization pattern. These patients were less likely to be asymptomatic at first presentation (13 of 32 versus 156 of 248 patients, P=0.02), and spontaneous type I ECG was more frequent among them (38% versus 21%, P=0.05). The spontaneous early repolarization pattern occurred more frequently among patients with BS than in 283 family members not having BS (11% versus 6%, P=0.03). Class I AAD administration provoked interior-lateral coved Brugada pattern in 13 patients with BS. These patients had longer baseline PR intervals (206 +/- 48 versus 172 +/- 31 ms, P<0.001) and class I AAD-induced QRS interval prolongation (108 to 178 versus 102 ms to 131 ms, P<0.001). In 3 patients, the class I AAD-provoked coved Brugada pattern was only present in the inferior leads. Conclusions-Inferior-lateral early repolarization pattern occurs spontaneously relatively frequently in BS. These patients have a more severe phenotype. Class I AAD administration provokes inferior-lateral coved Brugada pattern in 4.6% of patients. We report for the first time 3 patients in whom the class I AAD-provoked coved Brugada pattern was only observed in the inferior leads. (Circ Arrhythmia Electrophysiol. 2009;2:154-161.) |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Circulation. Arrhythmia and electrophysiology
| |
|
Publication
|
|
|
|
2009
| |
|
ISSN
|
|
|
|
1941-3149
| |
|
DOI
|
|
|
|
10.1161/CIRCEP.108.795153
| |
|
Volume/pages
|
|
|
|
2
:2
(2009)
, p. 154-161
| |
|
ISI
|
|
|
|
000266127400010
| |
|
Pubmed ID
|
|
|
|
19808460
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|