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Title
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Long-term follow-up of primary prophylactic implantable cardioverter-defibrillator therapy in Brugada syndrome
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Author
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Abstract
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| Aims To analyse the follow-up data of implantable cardioverter-defibrillator (ICD) therapy in Brugada syndrome (BS). Methods and results We conducted a retrospective, single centre study of 47 patients (mean age: 44.5 +/- 15 years) with BS, who underwent primary prophylactic ICD implantation. All patients had baseline spontaneous (23 patients) or drug-induced (24 patients) coved type I ECG pattern. All patients were judged to be at high risk because of syncope (26 patients) and/or a positive family history of sudden death (26 patients). During a median follow-up of 47.5 months, seven patients had appropriate shocks. The presence of spontaneous type I ECG and non-sustained ventricular tachyarrhythmia in the ICD datalog suggested a trend towards shorter appropriate shock-free survival by Kaplan-Meier analysis (P = 0.037 and P = 0.012, respectively). Seventeen patients received inappropriate shocks (IS); eight patients for sinus tachycardia; six patients for new onset atrial arrhythmias; and five patients for noise oversensing. In multivariable Cox-regression analysis, new onset atrial fibrillation (AF) and less than 50 years of age were independent predictors of significantly shorter IS-free survival (P = 0.04 and P = 0.036, respectively). Conclusion In high-risk patients with BS, primary prophylactic ICD therapy is an effective treatment. In this, young and otherwise healthy patient population, the IS rate is high. |
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Language
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English
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Source (journal)
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European heart journal. - London
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Publication
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London
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2007
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ISSN
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0195-668X
[Print]
1522-9645
[Online]
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DOI
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10.1093/EURHEARTJ/EHL450
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Volume/pages
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28
:3
(2007)
, p. 334-344
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ISI
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000244259800013
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Pubmed ID
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17251258
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Full text (Publisher's DOI)
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