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Title
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Early exposure to bio-contaminants and asthma up to 10 years of age : results of the HITEA study
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Author
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Institution/Organisation
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HITEA Study Grp
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Abstract
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| Inverse associations have been found between exposure to bio-contaminants and asthma and allergies. The aim of this study was to prospectively assess whether early exposure to bio-contaminants in dust is associated with asthma and allergy later in childhood among children from (sub)-urban areas. In subsets of three European birth cohorts (PIAMA: n=553; INMA: n=481; and LISAplus: n=395), endotoxin, (1,3,)-beta-D-glucan and extracellular polysaccharide were measured in dust from living rooms shortly after birth. Current asthma at 6 years and 10 years of age and ever asthma up to 10 years of age were assessed by parental questionnaires. Specific IgE levels at 8 years (PIAMA) and 10 years (LISAplus) were available. Adjusted, cohort-specific logistic regression analyses were performed. Higher endotoxin concentrations were positively associated with current asthma at 6 years of age in PIAMA (adjusted OR 1.96, 95% CI 1.07-3.58), but were inversely related with ever asthma up to 10 years of age in INMA (adjusted OR 0.39, 95% CI 0.16-0.94). No associations with asthma were found for LISAplus. No associations were observed with atopic sensitisation in all cohorts. All associations with (1,3,)-beta-D-glucan and extracellular polysaccharide were statistically nonsignificant. The suggested immunological mechanisms of early exposure to bio-contaminants with regards to asthma and allergy might be different for children growing up in (sub)-urban environments. |
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Language
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English
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Source (journal)
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The European respiratory journal / European Respiratory Society [Lausanne] - Copenhagen, 1988, currens
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Publication
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Copenhagen
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2015
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ISSN
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0903-1936
[print]
1399-3003
[online]
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DOI
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10.1183/09031936.00060214
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Volume/pages
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45
:2
(2015)
, p. 328-337
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ISI
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000349509700010
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Pubmed ID
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25186271
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Full text (Publisher's DOI)
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