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Title
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The role of sclerostin in bone and ectopic calcification
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Author
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Abstract
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| Sclerostin, a 22-kDa glycoprotein that is mainly secreted by the osteocytes, is a soluble inhibitor of canonical Wnt signaling. Therefore, when present at increased concentrations, it leads to an increased bone resorption and decreased bone formation. Serum sclerostin levels are known to be increased in the elderly and in patients with chronic kidney disease. In these patient populations, there is a high incidence of ectopic cardiovascular calcification. These calcifications are strongly associated with cardiovascular morbidity and mortality. Although data are still controversial, it is likely that there is a link between ectopic calcification and serum sclerostin levels. The main question, however, remains whether sclerostin exerts either a protective or deleterious role in the ectopic calcification process. |
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Language
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English
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Source (journal)
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International journal of molecular sciences
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Publication
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Basel
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Mdpi
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2020
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ISSN
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1422-0067
1661-6596
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DOI
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10.3390/IJMS21093199
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Volume/pages
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21
:9
(2020)
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Article Reference
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3199
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ISI
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000535581700170
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Pubmed ID
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32366042
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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