Title
Stimulatory effects of L-5-hydroxytryptophan on postdexamethasone beta-endorphin levels in major depression Stimulatory effects of L-5-hydroxytryptophan on postdexamethasone beta-endorphin levels in major depression
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York, N.Y. ,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
Neuropsychopharmacology. - New York, N.Y.
Volume/pages
15(1996) :4 , p. 340-348
ISSN
0893-133X
ISI
A1996VK31600004
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Recently it has been shown that acute administration of 200 mg L-5-hydroxytryptophan (L-5-HTP) PO may increase post-dexamethasone (DST) adrenocorticotropic hormone (ACTH) and cortisol levels in major, but not minor, depressed subjects. This study aimed to examine the effects of 200 mg L-5-HTP PO on post-DST beta-endorphin levels in the same depressed subjects. It was found that in major, but not minor, depressed subjects, L-5-HTP significantly increased post-DST beta-endorphin concentrations as compared to placebo. The L-5-HTP-induced post-DST beta-endorphin responses were significantly higher in major than in minor depressed subjects. There was a significant and positive relationship between L-5-HTP-induced post-DST beta-endorphin and ACTH or cortisol responses. There was a significant and positive relationship between L-5-HTP-induced post-DST beta-endorphin values and the Hamilton Depression Rating Scale (HDRS) score. The results show that the acute administration of L-5-HTP may increase the escape of beta-endorphin secretion from suppression by dexamethasome in major, but not minor, depression.
E-info
https://repository.uantwerpen.be/docman/iruaauth/43bdcb/0f52350.pdf
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Handle