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Title
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Stimulatory effects of L-5-hydroxytryptophan on postdexamethasone beta-endorphin levels in major depression
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Author
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Abstract
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| Recently it has been shown that acute administration of 200 mg L-5-hydroxytryptophan (L-5-HTP) PO may increase post-dexamethasone (DST) adrenocorticotropic hormone (ACTH) and cortisol levels in major, but not minor, depressed subjects. This study aimed to examine the effects of 200 mg L-5-HTP PO on post-DST beta-endorphin levels in the same depressed subjects. It was found that in major, but not minor, depressed subjects, L-5-HTP significantly increased post-DST beta-endorphin concentrations as compared to placebo. The L-5-HTP-induced post-DST beta-endorphin responses were significantly higher in major than in minor depressed subjects. There was a significant and positive relationship between L-5-HTP-induced post-DST beta-endorphin and ACTH or cortisol responses. There was a significant and positive relationship between L-5-HTP-induced post-DST beta-endorphin values and the Hamilton Depression Rating Scale (HDRS) score. The results show that the acute administration of L-5-HTP may increase the escape of beta-endorphin secretion from suppression by dexamethasome in major, but not minor, depression. |
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Language
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English
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Source (journal)
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Neuropsychopharmacology. - New York, N.Y.
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Publication
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New York, N.Y.
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1996
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ISSN
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0893-133X
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DOI
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10.1016/0893-133X(95)00238-9
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Volume/pages
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15
:4
(1996)
, p. 340-348
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ISI
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A1996VK31600004
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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