Publication
Title
Inflammation following trypanosome infection and persistence in the skin
Author
Abstract
Human African trypanosomes rely for their transmission on tsetse flies (Glossina sp.) that inoculate parasites into the skin during blood feeding. The absence of a protective vaccine, limited knowledge about the infection immunology, and the existence of asymptomatic carriers sustaining transmission are major outstanding challenges towards elimination. All these relate to the skin where (i) parasites persist and transmit to tsetse flies and (ii) a successful vaccination strategy should ideally be effective. Host immune processes and parasite strategies that underlie early infection and skin tropism are essential aspects to comprehend the transmission-success of trypanosomes and the failure in vaccine development. Recent insights into the early infection establishment may pave the way to novel strategies aimed at blocking transmission.
Language
English
Source (journal)
Current opinion in immunology. - London
Publication
London : 2020
ISSN
0952-7915
DOI
10.1016/J.COI.2020.04.006
Volume/pages
66 (2020) , p. 65-73
ISI
000601210400012
Pubmed ID
32446136
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Infla-Med: Fundamental and translational research into targets for the treatment of inflammatory diseases.
Exploring and targeting the kinome of immune cells exposed to African trypanosomes.
Modified 7-deazapurine nucleoside analogues for the treatment of human African trypanosomiasis: towards a strong proof-of-concept.
Veterinary and human parasitology.
Exploring and targeting the kinome of immune cells exposed to protozoan parasites.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 02.06.2020
Last edited 02.10.2024
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