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Title
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The use of 3 selected lactobacillary strains in vaginal probiotic gel for the treatment of acute Candida vaginitis : a proof-of-concept study
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Author
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Abstract
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| In vitro studies suggest that certain probiotic bacterial strains have potential activity against opportunistic infections such as Candida. There are few in vivo trials using probiotics as a single treatment for acute Candida vulvovaginitis (CV). In this open-label, proof-of-concept study, selected Lactobacillus strains were tested in women with acute Candida vaginitis. Twenty women diagnosed with proven, symptomatic CV were instructed to administer a vaginal probiotic gel with L. plantarum YUN-V2.0, L. pentosus YUN-V1.0 and L. rhamnosus YUN-S1.0 for 10 consecutive days. Vaginal rinsing fluid, vaginal culture swab and vaginal smear for fresh wet-mount microscopy were collected before and 7, 14 and 28 days after start of treatment. On average, participating women were 39 years old and had an history of 5 vaginal infections of which 95% was CV. Nine women (45%) completed the study without the need of rescue medication. Women who needed rescue treatment experienced twice as much Candida infections in the past. A negative correlation was found between the clinical composite score and the time to use rescue medication (R-2 = 0.127). Seventy-four per cent of participants found the study gel comfortable to use, and 42% of all women would use the tested gel again for this indication. Forty-five per cent of women were treated successfully for acute CV with a novel vaginal gel containing 3 selected Lactobacillus strains. Patients needing rescue treatment were suffering from more severe and long-standing disease. These results warrant for further testing of this new product, especially of its potential in cases with mild to moderate severity, as an adjuvant to antimycotics or as a preventive measure in women with recurrent vulvovaginal candidosis. |
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Language
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English
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Source (journal)
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European journal of clinical microbiology and infectious diseases. - Wiesbaden
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Publication
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New york
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Springer
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2020
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ISSN
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0934-9723
[print]
1435-4373
[online]
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DOI
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10.1007/S10096-020-03868-X
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Volume/pages
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p. 1-8
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ISI
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000529740100003
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Pubmed ID
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32356027
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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