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Title
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Spectrum of false positive F-18-sodium fluoride (NaF) bone PET/CT findings in Oncology imaging; A narrative pictorial review of cases from a single institution
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Author
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Abstract
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| Fluorine-18-sodium fluoride (F-18-NaF) is a positron emission tomography (PET) bone imaging agent mainly used for oncology staging but may also be used in the evaluation of benign bone and joint pathology conditions. Fluorine-18-NaF is an excellent bone-seeking agent with high bone uptake owing to favorable biodistribution with rapid single-pass extraction, limited plasma protein binding and prompt renal clearance. Fluorine-18-NaF PET/computed tomography (CT) is highly sensitive in identifying both sclerotic and lytic bone metastatic lesions. Occasionally F-18-NaF uptake in benign bone lesions can mimic malignantpathology. In these cases, the pattern of F-18-NaF uptake may elicit a specific diagnosis and correlation with clinical information and morphological information from correlative CT is essential for a correct diagnosis. In the present article, we present a series of clinical cases demonstrating examples of F-18-NaF uptake in benign lesions which can simulate malignant pathology in patients undergoing cancer staging. |
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Language
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English
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Publication
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Thessaloniki
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Hellenic soc nuclear medicine
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2020
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Volume/pages
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23
:1
(2020)
, p. 67-75
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ISI
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000531067900011
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Pubmed ID
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32361718
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Full text (Publisher's DOI)
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