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Title
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Correlation between apparent diffusion coefficient value on MRI and histopathologic WHO grades of neuroendocrine tumors
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Author
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Abstract
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| Background: The correlation of diffusion-weighted MRI and tumor aggressiveness has been established for different tumor types, which leads to the question if it could also apply for neuroendocrine tumors (NET). Purpose: To investigate the possible correlation between apparent diffusion coefficient (ADC) value on magnetic resonance imaging (MRI) and histopathologic WHO-grades of NET. Material and Methods: Electronic patient records from patients presented at the multidisciplinary neuro-endocrine tumor board between November 2017 and April 2019 were retrospectively reviewed. Patients with both available MR imaging (primary tumor or metastasis) and known WHO tumor grade were included (n = 47). Average and minimum ADC values (avgADC; minADC) were measured by drawing a freehand ROI excluding only the outermost border of the lesion. The largest axial size (primary tumor) or most clearly delineated lesion (metastasis) was used. Results: Forty seven patients met the inclusion criteria (mean age 59 +/- 12 SD; 24F/23M). Twenty one patients (45%) were diagnosed with WHO G1 tumor, 17 seventeen with G2 (36%) and nine with G3 (19%) tumor. Twenty eight primary tumors and 19 metastases were measured. A significant difference was found between low-grade (G1+G2) and high-grade (G3) tumors (Mann-Whitney; avgADC: p < 0,001; minADC: p = 0,001). There was a moderate negative correlation between WHO-grade and avgADC/minADC (Spearman; avgADC: -0,606; 95% CI [-0,773; -0,384]; minADC: -0,581; 95% CI [-0.759; -0.353]). Conclusion: Our data show a significant difference in both average and minimum ADC values on MRI between low and high grade NET. A moderate negative correlation was found between histopathologic WHO grade and ADC value. |
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Language
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English
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Source (journal)
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Journal of the Belgian Society of Radiology / Belgian Society of Radiology
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Publication
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Ubiquity Press
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2020
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ISSN
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2514-8281
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DOI
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10.5334/JBSR.1925
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Volume/pages
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104
:1
(2020)
, p. 1-9
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Article Reference
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7
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ISI
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000528239000007
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Pubmed ID
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32025623
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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