|
Title
|
|
|
|
Simplifying rabies vaccination schedules
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Shortened and simpler rabies PrEP and PEP ID schedules, using low-dose vaccine volumes can be considered as a good illustration of ‘less can be more’. The story of a first successful post-exposure treatment against rabies by Josef Meister, who was bitten by a rabid dog, was performed by Louis Pasteur in 1885. This treatment, which comprised 13 injections given over 9 days ended with the injection of a fully virulent virus. Today, the new post-exposure prophylaxis (PEP) recommended by World Health Organization (WHO) can be simplified to a total of six intradermal micro-injections (one dose of 0.1 mL in two separate arms) divided over 3 days in one week (day 0, day 3 and day 7). Our team evaluated shortened combined pre-exposure prophylaxis (PrEP) and PEP schedules over 3 days and 2 days in two randomised clinical trials, of which an adapted version is now promoted by WHO as first-line PrEP and PEP over in total 3 days. Bringing the rabies prevention schedule 134 years later from nine visits to three or to two assures clinical effectiveness of this regimen with a safer profile, better compliance, and drastically simplifies rabies prevention procedures for the traveller. |
| |
|
Language
|
|
|
|
Dutch
| |
|
Publication
|
|
|
|
Antwerp
:
University of Antwerp, Faculty of Medicine and Health Sciences
,
2020
| |
|
Volume/pages
|
|
|
|
178 p.
| |
|
Note
|
|
|
|
:
Bottieau, Emmanuel [Supervisor]
:
van Damme, Pierre [Supervisor]
| |
|
Full text (open access)
|
|
|
|
| |
|