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Title
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Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin
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Author
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Abstract
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| Monitoring the progression of non-alcoholic fatty liver disease is hindered by a lack of suitable non-invasive imaging methods. Here, we show that the endogenous pigment lipofuscin displays strong near-infrared and shortwave-infrared fluorescence when excited at 808 nm, enabling label-free imaging of liver injury in mice and the discrimination of pathological processes from normal liver processes with high specificity and sensitivity. We also show that the near-infrared and shortwave-infrared fluorescence of lipofuscin can be used to monitor the progression and regression of liver necroinflammation and fibrosis in mouse models of non-alcoholic fatty liver disease and advanced fibrosis, as well as to detect non-alcoholic steatohepatitis and cirrhosis in biopsied samples of human liver tissue. |
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Language
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English
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Source (journal)
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Nature Biomedical Engineering. - [S.l.]
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Publication
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London
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Nature publishing group
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2020
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ISSN
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2157-846X
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DOI
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10.1038/S41551-020-0569-Y
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Volume/pages
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4
(2020)
, p. 801-813
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ISI
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000542072600004
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Pubmed ID
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32572196
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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