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Title
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Antileishmanial aminopyrazoles : studies into mechanisms and stability of experimental drug resistance
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Author
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Abstract
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| Current antileishmanial treatment is hampered by limitations such as drug toxicity and the risk of treatment failure, which may be related to parasitic drug resistance. Given the urgent need for novel drugs, the Drugs for Neglected Diseases initiative (DNDi) has undertaken a drug discovery program, which has resulted in the identification of aminopyrazoles - a highly promising antileishmanial chemical series. Multiple experiments have been performed to anticipate the propensity for resistance development. |
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Language
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English
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Source (journal)
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Antimicrobial agents and chemotherapy. - Washington, D.C., 1972, currens
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Publication
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Washington, D.C.
:
American Society for Microbiology
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2020
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ISSN
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0066-4804
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DOI
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10.1128/AAC.00152-20
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Volume/pages
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64
:9
(2020)
, p. 1-15
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Article Reference
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AAC.00152-20
e00152-20
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ISI
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000590216000030
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Pubmed ID
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32601168
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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