|
Title
|
|
|
|
Prenylated flavonoids from the roots of Tephrosia rhodesica
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Five new compounds—rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)—along with 16 known secondary metabolites, were isolated from the CH2Cl2–CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2–5, 9, 15, and 21 showed activity (100% at 10 μg and IC50 = 5–15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Journal of natural products. - Columbus, Ohio, 1979, currens
| |
|
Publication
|
|
|
|
Columbus, Ohio
:
2020
| |
|
ISSN
|
|
|
|
0163-3864
| |
|
DOI
|
|
|
|
10.1021/ACS.JNATPROD.0C00245
| |
|
Volume/pages
|
|
|
|
83
:8
(2020)
, p. 2390-2398
| |
|
ISI
|
|
|
|
000566765000009
| |
|
Pubmed ID
|
|
|
|
32790306
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (open access)
|
|
|
|
| |
|