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Title
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Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis
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Author
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Institution/Organisation
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Int FTD-Genomics Consortium IFGC
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Abstract
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| We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n=similar to 38,000 for LTL and similar to 81,000 for ALS in the European population; n=similar to 23,000 for LTL and similar to 4,100 for ALS in the Asian population). We further evaluated mediation roles of lipids in the pathway from LTL to ALS. The odds ratio per standard deviation decrease of LTL on ALS was 1.10 (95% CI 0.93-1.31, p=0.274) in the European population and 0.75 (95% CI 0.53-1.07, p=0.116) in the Asian population. This null association was also detected between LTL and frontotemporal dementia in the European population. However, we found that an indirect effect of LTL on ALS might be mediated by low density lipoprotein (LDL) or total cholesterol (TC) in the European population. These results were robust against extensive sensitivity analyses. Overall, our MR study did not support the direct causal association between LTL and the ALS risk in neither population, but provided suggestive evidence for the mediation role of LDL or TC on the influence of LTL and ALS in the European population. |
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Language
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English
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Source (journal)
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Scientific reports. - London, 2011, currens
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Publication
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London
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Nature Publishing Group
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2020
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ISSN
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2045-2322
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DOI
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10.1038/S41598-020-68848-9
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Volume/pages
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10
:1
(2020)
, 12 p.
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Article Reference
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12184
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ISI
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000556401400011
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Pubmed ID
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32699404
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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