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Title
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Free running mouse brain PET imaging using point source motion tracking
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Author
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Abstract
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| In this work we aim to track the head motion of the awake mouse during the PET scan and correct the scan for motion to obtain motion-free brain images. The mouse head motion is tracked using radioactive point sources attached to the head (point source tracking, PST). In addition, a specially designed holder with a platform area of 9 × 10 cm was used to maintain the mouse inside the scanner field of view. Two mice were injected with [ 18 F]FDG and scanned awake during 20 min and under anesthesia 20 min to obtain a motion-free reconstruction for comparison. The mice moved over the entire available platform area. The average mouse head speed was 0.804 and 0.788 cm/s and the tracking success rate was 85.3% and 84.9% for the two mice respectively. After motion correction, the mouse brain FDG uptake pattern was recovered in the reconstructed image. The pearson's r correlation between awake and anesthesia reconstructions brain relative regional uptake was 0.875 and 0.986 the two mice respectively. The mouse head was successfully tracked using the PST method and the brain motion corrected reconstructions showed high correlation with motionfree reconstructions. |
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Language
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English
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Source (book)
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2017 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC, 21-28 Oct. 2017, Atlanta, GA, USA
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Publication
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2017
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ISBN
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978-1-5386-2282-7
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DOI
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10.1109/NSSMIC.2017.8532779
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Volume/pages
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p. 1-3
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ISI
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000455836200188
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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