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Title
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The use of small animal molecular imaging (μPET) exemplified in a neurobiological pathology
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Author
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Abstract
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| Positron emission tomography (PET) imaging is a molecular imaging modality with an extreme high versatility. Theoretically, all biological processes can be visualized longitudinally and quantified in vivo with high sensitivity, once a radioligand for a certain target of interest is developed. This chapter introduces the principle of PET and how relevant biological parameters can be extracted from PET images using pharmacokinetic modelling. In addition, we discuss awake PET imaging in small animal (μPET) studies. The novelty of point source tracking enables to follow tracer distribution in the brain of rodents during the conduct of certain (pathological) behavior. As a consequence, anesthesia-related factors are eliminated which continue to be an obstacle for bench-to-bedside translation. Lastly, this chapter emphasizes the value of μPET in the exploration and evaluation of disease mechanisms, as illustrated by a pharmacological and genetic rodent model for obsessive compulsive disorder (OCD). Longitudinal brain PET studies can be set up to investigate whether behavioral alterations parallel changes in the binding of radioligands for multiple targets. Altogether, μPET imaging provides unique whole brain information on underlying disease mechanisms and potential treatment targets, especially when the PET data are collected in awake animals. |
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Language
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English
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Source (book)
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PET and SPECT of neurobiological Ssystems/Dierckx,Rudi A.J.O. [edit.]; et al. [edit.]
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Publication
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Cham
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Springer
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2020
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ISBN
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978-3-030-53176-8
[online]
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978-3-030-53175-1
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DOI
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10.1007/978-3-030-53176-8_2
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Volume/pages
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p. 57-92
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Full text (Publisher's DOI)
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