Publication
Title
Ferroptosis : biological rust of lipid membranes
Author
Abstract
Significance:Iron is an essential element required for growth and proper functioning of the body. However, an excess of labile ferrous iron increases the risk of oxidative stress-induced injury due to the high reactivity of the unpaired reactive electrons of both ferrous iron and oxygen. This high reactivity can be exemplified in the outside world by one of its consequences, rust formation. In cells, this redox-active iron is involved in the formation of lipid radicals. Recent Advances:Defect or insufficient membrane-protective mechanisms can result in iron-catalyzed excessive lipid peroxidation and subsequent cell death, now conceptualized as ferroptosis. Growing reports propose the detrimental role of iron and ferroptosis in many experimental disease models such as ischemia-reperfusion, acute and chronic organ injuries. Critical Issues:This review first provides a snapshot of iron metabolism, followed by a brief introduction of the molecular mechanisms of ferroptosis, as an iron-dependent lipid peroxidation-driven mode of cell death. Upon describing how iron dysbiosis affects ferroptosis induction, we elaborate on the detrimental role of the iron-ferroptosis axis in several diseases. Future Directions:Despite compelling findings suggesting a role of ferroptosis in experimental animal models, the exact contribution of ferroptosis in human contexts still needs further investigation. Development of reliable ferroptosis biomarkers will be an important step in characterizing ferroptosis in human disease. This can provide therapeutic opportunities aiming at targeting ferroptosis in human diseases.
Language
English
Source (journal)
Antioxidants and redox signaling. - -
Publication
New rochelle : Mary ann liebert, inc , 2020
ISSN
1557-7716 [online]
1523-0864 [print]
DOI
10.1089/ARS.2020.8175
Volume/pages
p. 1-23
ISI
000568313800001
Pubmed ID
32808533
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Investigating the role of ferroptosis in acute liver injury and multiple sclerosis with newly developed chemical tool compounds.
Validation of ferroptosis-sensitizing combination therapies in patientderived neuroblastoma models.
Overcoming cell cycle arrest in injured kidneys: key to efficient renal regeneration.
Infla-Med: Fundamental and translational research into targets for the treatment of inflammatory diseases.
Cell death detection platform.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 19.10.2020
Last edited 04.12.2024
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