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Title
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Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides
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Author
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Abstract
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| A superoxide dismutases mimic (Mn1) was functionalized with three positively charged-peptides: RRRRRRRRR (Mn1-R9), RRWWWRRWRR (Mn1-RW9) or Fxr-Fx-K (Mn1-MPP). Characterization of the physico-chemical properties of the complexes show that they share similar binding affinity for Mn2+, apparent reduction potential and intrinsic superoxide dismutase activity. However, their accumulation in cells is different (Mn1-R9 < Mn1-MPP < Mn1-RW9 < Mn1), as well as their subcellular distribution. In addition, the three functionalized-complexes display a better anti-inflammatory activity than Mn1 when assayed at 10 μM. This improvement is due to a combination of an anti-inflammatory effect of the peptidyl moiety itself, and of the SOD mimic for Mn1-RW9 and Mn1-MPP. In contrast, the enhanced anti-inflammatory activity of Mn1-R9 is solely due to the SOD mimic. |
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Language
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English
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Source (journal)
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Dalton Transactions : an international journal of inorganic chemistry / Royal Society of Chemistry [London] - Cambridge, 2003, currens
Journal of the Chemical Society : Dalton transactions. - London, 1972 - 1999
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Publication
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Cambridge
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Royal Society of Chemistry
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2020
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ISSN
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1477-9226
[print]
1477-9234
[online]
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DOI
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10.1039/C9DT04619D
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Volume/pages
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49
:7
(2020)
, p. 2323-2330
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ISI
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000515660700032
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Full text (Publisher's DOI)
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