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Title
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Endurance exercise intervention is beneficial to kidney function in a rat model of isolated abdominal venous congestion : a pilot study
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Author
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Abstract
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| In this study, the effects of moderate intense endurance exercise on heart and kidney function and morphology were studied in a thoracic inferior vena cava constricted (IVCc) rat model of abdominal venous congestion. After IVC surgical constriction, eight sedentary male Sprague-Dawley IVCc rats (IVCc-SED) were compared to eight IVCc rats subjected to moderate intense endurance exercise (IVCc-MOD). Heart and kidney function was examined and renal functional reserve (RFR) was investigated by administering a high protein diet (HPD). After 12 weeks of exercise training, abdominal venous pressure, indices of body fat content, plasma cystatin C levels, and post-HPD urinary KIM-1 levels were all significantly lower in IVCc-MOD versus IVCc-SED rats (P < 0.05). RFR did not differ between both groups. The implementation of moderate intense endurance exercise in the IVCc model reduces abdominal venous pressure and is beneficial to kidney function. |
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Language
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English
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Source (journal)
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Journal of cardiovascular translational research
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Publication
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2020
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ISSN
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1937-5387
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DOI
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10.1007/S12265-019-09947-5
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Volume/pages
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13
:5
(2020)
, p. 769-782
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ISI
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000574487900002
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Pubmed ID
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31848881
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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