Publication
Title
Resting brain fluctuations are intrinsically coupled to visual response dynamics
Author
Abstract
How do intrinsic brain dynamics interact with processing of external sensory stimuli? We sought new insights using functional magnetic resonance imaging to track spatiotemporal activity patterns at the whole brain level in lightly anesthetized mice, during both resting conditions and visual stimulation trials. Our results provide evidence that quasiperiodic patterns (QPPs) are the most prominent component of mouse resting brain dynamics. These QPPs captured the temporal alignment of anticorrelation between the default mode (DMN)- and task-positive (TPN)-like networks, with global brain fluctuations, and activity in neuromodulatory nuclei of the reticular formation. Specifically, the phase of QPPs prior to stimulation could significantly stratify subsequent visual response magnitude, suggesting QPPs relate to brain state fluctuations. This is the first observation in mice that dynamics of the DMN- and TPN-like networks, and particularly their anticorrelation, capture a brain state dynamic that affects sensory processing. Interestingly, QPPs also displayed transient onset response properties during visual stimulation, which covaried with deactivations in the reticular formation. We conclude that QPPs appear to capture a brain state fluctuation that may be orchestrated through neuromodulation. Our findings provide new frontiers to understand the neural processes that shape functional brain states and modulate sensory input processing.
Language
English
Source (journal)
Cerebral cortex. - New York
Publication
New York : 2021
ISSN
1047-3211
DOI
10.1093/CERCOR/BHAA305
Volume/pages
31 :3 (2021) , p. 1511-1522
Article Reference
bhaa305
ISI
000637026100008
Pubmed ID
33108464
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Imaging of Neuroinflammation in Neurodegenerative Diseases (INMIND).
Molecular Imaging of Brain Pathophysiology (BrainPath).
Ultrafast Functional Ultrasound (fUS) Imaging for highly resolved targetted mapping of functional connectivity in the awake mouse brain (FUSIMICE).
Improved classification of Alzheimer's disease: differentiation of slow propagating waves of BOLD intensity of dynamic rsfMRI in AD mice models in pre-plaque and post-plaque stages.
Multimodal Imaging of cholinergic neuromodulation during specific memory phases in the rodent brain.
Neuro Image-guided decoding of mechanisms involved in healthy, accelerated and pathological aging.
Amyloid β and sleep problems, a neurotoxic pas de deux during aging?
Improved classification of Alzheimer's disease assessed from the slowly propagating waves of BOLD intensity, the Quasi-Periodic patterns, observed in dynamic resting-state fMRI in a AD rat model at rest and upon sensory stimulation.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 01.11.2020
Last edited 13.11.2024
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