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Title
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Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis
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Author
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Abstract
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| Background: Muscle carnosine is related to contractile function (Ca+ + handling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS. Methods: Tibialis anterior muscle carnosine was measured in an animal MS model (EAE, experimental autoimmune encephalomyelitis, n = 40) and controls (CONEX, n = 40) before and after exercise training (EAE(EX), CONEX, 10d, 1 h/d, 24 m/min treadmill running) or sedentary conditions (EAE(SED), CONSED). Human m. vastus lateralis carnosine of healthy controls (HC, n = 22) and MS patients (n = 24) was measured. Results: EAE muscle carnosine levels were decreased (p < .0001) by similar to 40% to similar to 64% at 10d and 17d following EAE induction (respectively) regardless of exercise (p = .823). Similarly, human MS muscle carnosine levels were decreased (- 25%, p = .03). Conclusion: Muscle carnosine concentrations in an animal MS model and MS patients are substantially reduced. In EAE exercise therapy does not restore this. |
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Language
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English
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Source (journal)
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Multiple Sclerosis and Related Disorders
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Publication
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2018
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ISSN
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2211-0348
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DOI
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10.1016/J.MSARD.2018.02.013
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Volume/pages
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21
(2018)
, p. 24-29
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ISI
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000432725300007
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Pubmed ID
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29454153
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Full text (Publisher's DOI)
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