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Title
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Exercise-onset heart rate increase is slowed in multiple sclerosis patients: Does a disturbed cardiac autonomic control affect exercise tolerance?
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Author
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Abstract
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| OBJECTIVE: To explore the etiology of exercise intolerance in patients with MS, it is analyzed whether a disturbed cardiac autonomic control could be observed during exercise testing in patients with MS, and is related to exercise tolerance. PATIENTS AND METHOD: From 26 MS patients and 15 healthy subjects, exercise-onset (first 20 and 60 seconds) and -offset (1-minute recovery) HR change was determined during a 6-minute constant-load exercise bout on bike. Blood lactate, HR, oxygen uptake, expiratory volume and perceived exertion were assessed during exercise, and compared between groups. In 15 MS patients, a 6-min walking test was executed. RESULT: Twenty-second exercise-onset HR increase was significantly smaller in MS patients (14 +/- 7 bts/min) vs. healthy subjects (20 +/- 8 bts/min, p < 0.05), and independently related to MS and age in total group (p < 0.05). Sixty-second exercise-onset and -offset HR changes were not different between groups, nor independently related to MS presence (p > 0.05). A significant correlation was found between 20-second exercise-onset HR increase and walking capacity in MS patients (r = 0.64, p < 0.01). CONCLUSION: In MS patients, the early increase in heart rate during endurance exercise is significantly slowed, indicating a disturbed cardiac autonomic control, and is related to exercise tolerance. |
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Language
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English
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Source (journal)
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Neurorehabilitation. - Reading, Mass.
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Publication
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Reading, Mass.
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2013
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ISSN
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1053-8135
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DOI
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10.3233/NRE-130938
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Volume/pages
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33
:1
(2013)
, p. 139-146
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ISI
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000324260400018
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Pubmed ID
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23949040
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Full text (Publisher's DOI)
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