Patients with the metabolic syndrome and a disturbed cortisol balance display more microalbuminuria

Janssen, Sarah F.; Twickler, Theodorus B.; Jublanc, Christel; Cramer, Maarten J.; Bruckert, Eric

doi:10.3132/DVDR.2008.010

Title

Patients with the metabolic syndrome and a disturbed cortisol balance display more microalbuminuria

Author

Janssen, Sarah F.

Twickler, Theodorus B.

Jublanc, Christel

Cramer, Maarten J.

Bruckert, Eric

Abstract

The objective of this study was to investigate whether patients with the metabolic syndrome (MetS) and an imbalance in cortisol metabolism express increased urinary albumin excretion compared to those patients with metabolic syndrome alone. Seventy-four patients with MetS were evaluated using a low-dose dexamethasone suppression test (LDDST) to identify disturbed cortisol balance (cortisol levels > 50 nmol/L after LDDST). The level of albumin in the urine was also evaluated. Disturbed cortisol balance was found in 8% of all evaluated patients with MetS. Microalbuminuria was present significantly more often (p<0.01) in those patients with MetS and an imbalance in cortisol metabolism compared with patients suffering MetS alone (urine albumin: 210 mg/L vs. 26 mg/L, respectively, p<0.01). A substantial percentage of patients with MetS had inappropriate cortisol homeostasis. Of importance, excretion of urinary albumin was increased in these patients. This observation may indicate that this subgroup within the MetS population has a higher cardiovascular risk and possible increased endothelial dysfunction, with a subsequent need for stricter control to prevent cardiovascular morbidity and mortality.

Language

English

Source (journal)

Diabetes & vascular disease research. - -

Publication

2008

ISSN

1479-1641

1752-8984

DOI

10.3132/DVDR.2008.010

Volume/pages